Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

The Mre11 complex (Mre11-Rad50-Nbs1 or MRN) binds double-strand breaks where it interacts with CtIP/Ctp1/Sae2 and ATM/Tel1 to preserve genome stability through its functions in homology-directed repair, checkpoint signaling and telomere maintenance. Here, we combine biochemical, structural and in vi...

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Detalles Bibliográficos
Autores principales: Limbo, Oliver, Moiani, Davide, Kertokalio, Aryandi, Wyman, Claire, Tainer, John A., Russell, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526295/
https://www.ncbi.nlm.nih.gov/pubmed/23080121
http://dx.doi.org/10.1093/nar/gks954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526295/
https://www.ncbi.nlm.nih.gov/pubmed/23080121
http://dx.doi.org/10.1093/nar/gks954

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