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Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution
Multivalent molecular interactions can be exploited to dramatically enhance the performance of an affinity reagent. The enhancement in affinity and specificity achieved with a multivalent construct depends critically on the effectiveness of the scaffold that joins the ligands, as this determines the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526301/ https://www.ncbi.nlm.nih.gov/pubmed/23042245 http://dx.doi.org/10.1093/nar/gks899 |