Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

The CD3ε and ζ cytoplasmic domains of the T cell receptor bind to the inner leaflet of the plasma membrane (PM), and a previous nuclear magnetic resonance structure showed that both tyrosines of the CD3ε immunoreceptor tyrosine-based activation motif partition into the bilayer. Electrostatic interac...

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Detalles Bibliográficos
Autores principales: Gagnon, Etienne, Schubert, David A., Gordo, Susana, Chu, H. Hamlet, Wucherpfennig, Kai W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526357/
https://www.ncbi.nlm.nih.gov/pubmed/23166358
http://dx.doi.org/10.1084/jem.20120790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526357/
https://www.ncbi.nlm.nih.gov/pubmed/23166358
http://dx.doi.org/10.1084/jem.20120790

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