Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing

BACKGROUND: Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given phenotype. In models like Xenopus tropicalis,...

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Detalles Bibliográficos
Autores principales: del Viso, Florencia, Bhattacharya, Dipankan, Kong, Yong, Gilchrist, Michael J, Khokha, Mustafa K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526394/
https://www.ncbi.nlm.nih.gov/pubmed/23171430
http://dx.doi.org/10.1186/1471-2164-13-649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526394/
https://www.ncbi.nlm.nih.gov/pubmed/23171430
http://dx.doi.org/10.1186/1471-2164-13-649

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