Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis

BACKGROUND: Ascites may affect the progression of ovarian cancer (OC). In particular, soluble factors present in OC ascites can create a protective environment for tumor cells that promote de novo resistance to drug- and death receptor-induced apoptosis. However, the underlying molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Goncharenko-Khaider, Nadzeya, Matte, Isabelle, Lane, Denis, Rancourt, Claudine, Piché, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526430/
https://www.ncbi.nlm.nih.gov/pubmed/23158473
http://dx.doi.org/10.1186/1476-4598-11-84

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526430/
https://www.ncbi.nlm.nih.gov/pubmed/23158473
http://dx.doi.org/10.1186/1476-4598-11-84

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