A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

BACKGROUND: The major rate-limiting enzyme for de novo cholesterol synthesis is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). HMGCR is sterically inhibited by statins, the most commonly prescribed drugs for the prevention of cardiovascular events. Alternative splicing of HMGCR has been im...

Descripción completa

Detalles Bibliográficos
Autores principales: Stormo, Camilla, Kringen, Marianne K, Grimholt, Runa M, Berg, Jens P, Piehler, Armin P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526503/
https://www.ncbi.nlm.nih.gov/pubmed/22989091
http://dx.doi.org/10.1186/1471-2199-13-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526503/
https://www.ncbi.nlm.nih.gov/pubmed/22989091
http://dx.doi.org/10.1186/1471-2199-13-29

Ejemplares similares