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A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

BACKGROUND: The major rate-limiting enzyme for de novo cholesterol synthesis is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). HMGCR is sterically inhibited by statins, the most commonly prescribed drugs for the prevention of cardiovascular events. Alternative splicing of HMGCR has been im...

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Detalles Bibliográficos
Autores principales:	Stormo, Camilla, Kringen, Marianne K, Grimholt, Runa M, Berg, Jens P, Piehler, Armin P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526503/ https://www.ncbi.nlm.nih.gov/pubmed/22989091 http://dx.doi.org/10.1186/1471-2199-13-29

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