The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

BACKGROUND: The P2X(7) receptor plays an important role in cytokine release during the inflammatory response in vivo. Polymorphisms within the P2X(7) receptor gene that lead to loss of receptor function may contribute to impaired cytokine release by immune cells. Therefore, we investigated whether a...

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Detalles Bibliográficos
Autores principales: Wesselius, Anke, Bours, Martijn JL, Arts, Ilja CW, Theunisz, Esther HE, Geusens, Piet, Dagnelie, Pieter C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526505/
https://www.ncbi.nlm.nih.gov/pubmed/23210974
http://dx.doi.org/10.1186/1471-2172-13-64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526505/
https://www.ncbi.nlm.nih.gov/pubmed/23210974
http://dx.doi.org/10.1186/1471-2172-13-64

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