Inactivation of MARCH5 Prevents Mitochondrial Fragmentation and Interferes with Cell Death in a Neuronal Cell Model

PURPOSE: To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions. METHODS: RGC5 cells transfected with expression constructs for MARCH5,...

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Detalles Bibliográficos
Autores principales: Fang, Lei, Hemion, Charles, Goldblum, David, Meyer, Peter, Orgül, Selim, Frank, Stephan, Flammer, Josef, Neutzner, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526576/
https://www.ncbi.nlm.nih.gov/pubmed/23285122
http://dx.doi.org/10.1371/journal.pone.0052637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526576/
https://www.ncbi.nlm.nih.gov/pubmed/23285122
http://dx.doi.org/10.1371/journal.pone.0052637

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