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Phylogenetic conservation of the 3′ cryptic recombination signal sequence (3′cRSS) in the VH genes of jawed vertebrates
The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, whi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526766/ https://www.ncbi.nlm.nih.gov/pubmed/23267360 http://dx.doi.org/10.3389/fimmu.2012.00392 |