Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression

Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gona...

Descripción completa

Detalles Bibliográficos
Autores principales: Warr, Nick, Carre, Gwenn-Aël, Siggers, Pam, Faleato, Jessica Vitos, Brixey, Rachel, Pope, Madeleine, Bogani, Debora, Childers, Melissa, Wells, Sara, Scudamore, Cheryl L., Tedesco, Marianna, del Barco Barrantes, Ivan, Nebreda, Angel R., Trainor, Paul A., Greenfield, Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526779/
https://www.ncbi.nlm.nih.gov/pubmed/23102580
http://dx.doi.org/10.1016/j.devcel.2012.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526779/
https://www.ncbi.nlm.nih.gov/pubmed/23102580
http://dx.doi.org/10.1016/j.devcel.2012.09.016

Ejemplares similares