Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression

Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gona...

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Detalles Bibliográficos
Autores principales: Warr, Nick, Carre, Gwenn-Aël, Siggers, Pam, Faleato, Jessica Vitos, Brixey, Rachel, Pope, Madeleine, Bogani, Debora, Childers, Melissa, Wells, Sara, Scudamore, Cheryl L., Tedesco, Marianna, del Barco Barrantes, Ivan, Nebreda, Angel R., Trainor, Paul A., Greenfield, Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526779/
https://www.ncbi.nlm.nih.gov/pubmed/23102580
http://dx.doi.org/10.1016/j.devcel.2012.09.016

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