Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

Cholesterol is known to modulate the physical properties of cell membranes but its direct involvement in cellular signaling has not been thoroughly investigated. Here we show that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-terminal PDZ domain of NHERF...

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Detalles Bibliográficos
Autores principales: Sheng, Ren, Chen, Yong, Gee, Heon Yung, Stec, Ewa, Melowic, Heather R., Blatner, Nichole R., Tun, Moe P., Kim, Yonjung, Källberg, Morten, Fujiwara, Takahiro K., Hong, Ji Hye, Kim, Kwang Pyo, Lu, Hui, Kusumi, Akihiro, Lee, Min Goo, Cho, Wonhwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526836/
https://www.ncbi.nlm.nih.gov/pubmed/23212378
http://dx.doi.org/10.1038/ncomms2221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526836/
https://www.ncbi.nlm.nih.gov/pubmed/23212378
http://dx.doi.org/10.1038/ncomms2221

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