Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV(1)), and its ratio to forced vital capacity (FEV(1)/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted g...

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Detalles Bibliográficos
Autores principales: Hancock, Dana B., Artigas, María Soler, Gharib, Sina A., Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W., Imboden, Medea, Koch, Beate, McArdle, Wendy L., Smith, Albert V., Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B., Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin M., Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B., Janson, Christer, Homuth, Georg, Hysi, Pirro G., Liu, Jason Z., Loehr, Laura R., Lohman, Kurt, Loos, Ruth J. F., Manning, Alisa K., Marciante, Kristin D., Obeidat, Ma'en, Postma, Dirkje S., Aldrich, Melinda C., Brusselle, Guy G., Chen, Ting-hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I., Wijmenga, Cisca, Williams, O. Dale, Bentley, Amy R., Hofman, Albert, Laurie, Cathy C., Lumley, Thomas, Morrison, Alanna C., Joubert, Bonnie R., Rivadeneira, Fernando, Couper, David J., Kritchevsky, Stephen B., Liu, Yongmei, Wjst, Matthias, Wain, Louise V., Vonk, Judith M., Uitterlinden, André G., Rochat, Thierry, Rich, Stephen S., Psaty, Bruce M., O'Connor, George T., North, Kari E., Mirel, Daniel B., Meibohm, Bernd, Launer, Lenore J., Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J., Gläser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J., Völzke, Henry, Stricker, Bruno H. C., Spector, Timothy D., Probst-Hensch, Nicole M., Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R., Gudnason, Vilmundur, Boezen, H. Marike, Barr, R. Graham, Cassano, Patricia A., Strachan, David P., Fornage, Myriam, Hall, Ian P., Dupuis, Josée, Tobin, Martin D., London, Stephanie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527213/
https://www.ncbi.nlm.nih.gov/pubmed/23284291
http://dx.doi.org/10.1371/journal.pgen.1003098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527213/
https://www.ncbi.nlm.nih.gov/pubmed/23284291
http://dx.doi.org/10.1371/journal.pgen.1003098

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