A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Numerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we describe an RNA interference (RNAi)–based synthetic interaction screen to identify g...

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Detalles Bibliográficos
Autores principales: Xie, Li, Gazin, Claude, Park, Sung Mi, Zhu, Lihua J., Debily, Marie-anne, Kittler, Ellen L. W., Zapp, Maria L., Lapointe, David, Gobeil, Stephane, Virbasius, Ching-Man, Green, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527276/
https://www.ncbi.nlm.nih.gov/pubmed/23284306
http://dx.doi.org/10.1371/journal.pgen.1003151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527276/
https://www.ncbi.nlm.nih.gov/pubmed/23284306
http://dx.doi.org/10.1371/journal.pgen.1003151

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