Cargando…

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Numerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we describe an RNA interference (RNAi)–based synthetic interaction screen to identify g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Li, Gazin, Claude, Park, Sung Mi, Zhu, Lihua J., Debily, Marie-anne, Kittler, Ellen L. W., Zapp, Maria L., Lapointe, David, Gobeil, Stephane, Virbasius, Ching-Man, Green, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527276/ https://www.ncbi.nlm.nih.gov/pubmed/23284306 http://dx.doi.org/10.1371/journal.pgen.1003151

Ejemplares similares

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein
por: Bhatnagar, Sanchita, et al.
Publicado: (2014)

Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy
por: Himeda, Charis L., et al.
Publicado: (2018)

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data
por: Zhu, Lihua J, et al.
Publicado: (2010)

A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
por: Guo, Sujuan, et al.
Publicado: (2018)

Author Correction: A large-scale RNA interference screen identifies genes that regulate autophagy at different stages
por: Guo, Sujuan, et al.
Publicado: (2019)

hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions
por: Silva, Tanielly Cristina Raiol, et al.
Publicado: (2012)

Genome-protective topoisomerase 2a-dependent G2 arrest requires p53 in hTERT-positive cancer cells
por: Lockwood, Nicola, et al.
Publicado: (2022)

Natural Presentation of Glycosaminoglycans in Synthetic Matrices for 3D Angiogenesis Models
por: Zapp, Cornelia, et al.
Publicado: (2021)

TERT promoter mutations and monoallelic activation of TERT in cancer
por: Huang, F W, et al.
Publicado: (2015)

Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs
por: Bernal, Aina, et al.
Publicado: (2018)

Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
por: Dratwa, Marta, et al.
Publicado: (2022)

2,7,11,16‐Tetra‐tert‐Butyl Tetraindenopyrene Revisited by an “Inverse” Synthetic Approach
por: Elbert, Sven M., et al.
Publicado: (2020)

Alterations in p53 Influence hTERT, VEGF and MMPs Expression in Oral Cancer Patients
por: Singh, Ragini D, et al.
Publicado: (2022)

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L
por: Pedanou, Victoria E, et al.
Publicado: (2016)

Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer
por: Hao, Suisui, et al.
Publicado: (2022)

The requirement of p53 for maintaining chromosomal stability during tetraploidization
por: Ho, Chui Chui, et al.
Publicado: (2010)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Synthetic lethality between TP53 and ENDOD1
por: Tang, Zizhi, et al.
Publicado: (2022)

(R)-N-{2-tert-Butyl-2-[(R)-tert-butylsulfonamido]ethylidene}-tert-butanesulfonamide
por: Hu, Yu, et al.
Publicado: (2008)

Chromosome instability and expression of BRAF, TERT and P53 in macrophage murine cell line (J774-1)
por: Polloni, Lorena, et al.
Publicado: (2014)

Adipose-Derived Mesenchymal Stem Cell (MSC) Immortalization by Modulation of hTERT and TP53 Expression Levels
por: Rakhmatullina, Aigul R., et al.
Publicado: (2023)

Recent Synthetic Approaches towards Small Molecule Reactivators of p53
por: Silva, Jerson L., et al.
Publicado: (2020)

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
por: Bou Samra, Elias, et al.
Publicado: (2017)

RD53B Design Requirements
por: Garcia-Sciveres, Maurice
Publicado: (2019)

Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody
por: Masui, Kenta, et al.
Publicado: (2018)

Targeted Long-Read Bisulfite Sequencing Identifies Differences in the TERT Promoter Methylation Profiles between TERT Wild-Type and TERT Mutant Cancer Cells
por: Lee, Seungjae, et al.
Publicado: (2022)

Unité mobile de soins pour la prise en charge d’infections à transmission aérienne
por: Gazin, Pierre
Publicado: (2022)

Laveran et l’éradication du paludisme en Corse
por: Gazin, Pierre
Publicado: (2023)

Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants
por: Iben, James R., et al.
Publicado: (2011)

TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter
por: Hafezi, François, et al.
Publicado: (2021)

A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression
por: Malhotra, Sanandan, et al.
Publicado: (2017)

p53/58 Binds COPI and Is Required for Selective Transport through the Early Secretory Pathway
por: Tisdale, Ellen J., et al.
Publicado: (1997)

Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation
por: McKenna, Declan J., et al.
Publicado: (2012)

Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern Italy
por: Lombardo, Daniele, et al.
Publicado: (2020)

4-tert-Butylpyridinium triiodide–4-tert-butylpyridine (1/1)
por: He, Hongshan, et al.
Publicado: (2011)

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma
por: Xie, Hong, et al.
Publicado: (2014)

TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
por: Vallarelli, Andrelou F., et al.
Publicado: (2016)

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
por: Stern, Josh Lewis, et al.
Publicado: (2015)

Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(−/−) mice
por: Zhou, Q-G, et al.
Publicado: (2016)

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression
por: Salgado, Catarina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_iht84ts9lrmbgnoq7m3q1lutt4