Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues

The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tes...

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Detalles Bibliográficos
Autores principales: Nelissen, Jo, Nuyts, Koen, De Zotti, Marta, Lavigne, Rob, Lamberigts, Chris, De Borggraeve, Wim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527430/
https://www.ncbi.nlm.nih.gov/pubmed/23284749
http://dx.doi.org/10.1371/journal.pone.0051708
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author Nelissen, Jo
Nuyts, Koen
De Zotti, Marta
Lavigne, Rob
Lamberigts, Chris
De Borggraeve, Wim M.
author_facet Nelissen, Jo
Nuyts, Koen
De Zotti, Marta
Lavigne, Rob
Lamberigts, Chris
De Borggraeve, Wim M.
author_sort Nelissen, Jo
collection PubMed
description The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.
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spelling pubmed-35274302013-01-02 Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues Nelissen, Jo Nuyts, Koen De Zotti, Marta Lavigne, Rob Lamberigts, Chris De Borggraeve, Wim M. PLoS One Research Article The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity. Public Library of Science 2012-12-20 /pmc/articles/PMC3527430/ /pubmed/23284749 http://dx.doi.org/10.1371/journal.pone.0051708 Text en © 2012 Nelissen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nelissen, Jo
Nuyts, Koen
De Zotti, Marta
Lavigne, Rob
Lamberigts, Chris
De Borggraeve, Wim M.
Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title_full Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title_fullStr Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title_full_unstemmed Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title_short Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues
title_sort total synthesis of septocylindrin b and c-terminus modified analogues
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527430/
https://www.ncbi.nlm.nih.gov/pubmed/23284749
http://dx.doi.org/10.1371/journal.pone.0051708
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