A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

BACKGROUND: SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD(+)-dependent deacetylase involved in the regulation of energy homeostasis and the modulation of various metabolic pathways, including glucose metabolism, oxidative stress and lipid metabolism. SIRT1 has be...

Descripción completa

Detalles Bibliográficos
Autores principales: Libri, Vincenzo, Brown, Andrew P., Gambarota, Giulio, Haddad, Jonathan, Shields, Gregory S., Dawes, Helen, Pinato, David J., Hoffman, Ethan, Elliot, Peter J., Vlasuk, George P., Jacobson, Eric, Wilkins, Martin R., Matthews, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527451/
https://www.ncbi.nlm.nih.gov/pubmed/23284689
http://dx.doi.org/10.1371/journal.pone.0051395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527451/
https://www.ncbi.nlm.nih.gov/pubmed/23284689
http://dx.doi.org/10.1371/journal.pone.0051395

Ejemplares similares