Cargando…

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for the disease was identified as an unstable expansion of CAG repeats in the gene encoding the huntingtin protein in 1993, n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menalled, Liliana B., Kudwa, Andrea E., Miller, Sam, Fitzpatrick, Jon, Watson-Johnson, Judy, Keating, Nicole, Ruiz, Melinda, Mushlin, Richard, Alosio, William, McConnell, Kristi, Connor, David, Murphy, Carol, Oakeshott, Steve, Kwan, Mei, Beltran, Jose, Ghavami, Afshin, Brunner, Dani, Park, Larry C., Ramboz, Sylvie, Howland, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527464/ https://www.ncbi.nlm.nih.gov/pubmed/23284626 http://dx.doi.org/10.1371/journal.pone.0049838

Ejemplares similares

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits
por: Kudwa, Andrea E., et al.
Publicado: (2013)

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease
por: Oakeshott, Stephen, et al.
Publicado: (2012)

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
por: Curtin, Paul C. P., et al.
Publicado: (2016)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease
por: Balci, Fuat, et al.
Publicado: (2013)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
por: Schindler, Franziska, et al.
Publicado: (2021)

Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease
por: Oakeshott, Stephen, et al.
Publicado: (2011)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington’s Disease
por: Oakeshott, Stephen, et al.
Publicado: (2013)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
por: Merino, Marián, et al.
Publicado: (2023)

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay
por: Papadopoulou, Aikaterini S., et al.
Publicado: (2019)

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
por: Deng, Yunping, et al.
Publicado: (2020)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

HD mouse models reveal clear deficits in learning to perform a simple instrumental response
por: Oakeshott, Stephen, et al.
Publicado: (2011)

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches
por: Smith, Edward J, et al.
Publicado: (2023)

Search for t to Zq
por: CMS Collaboration
Publicado: (2012)

Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction
por: Ferris, Craig F., et al.
Publicado: (2014)

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
por: Wang, Huei-Bin, et al.
Publicado: (2018)

Effect of the rd1 mutation on motor performance in R6/2 and wild type mice
por: Menalled, Liliana, et al.
Publicado: (2012)

Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
por: Huhtala, Tuulia, et al.
Publicado: (2019)

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum
por: Pinchaud, Katleen, et al.
Publicado: (2023)

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
por: Landles, Christian, et al.
Publicado: (2012)

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
por: Loupe, Jacob M, et al.
Publicado: (2020)

Genetic Knock-Down of Hdac3 Does Not Modify Disease-Related Phenotypes in a Mouse Model of Huntington's Disease
por: Moumné, Lara, et al.
Publicado: (2012)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
por: Marchionini, Deanna M., et al.
Publicado: (2022)

Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline
por: Menalled, Liliana B., et al.
Publicado: (2010)

Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
por: Franich, Nicholas R., et al.
Publicado: (2019)

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease
por: Tanimura, Asami, et al.
Publicado: (2016)

Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
por: Li, Si Han, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fv0f7138qj10abi8ovkumeplcv