Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators

The structure of the Fab region of antibodies is critical to their function. By introducing single cysteine substitutions into various positions of the heavy and light chains of the Fab region of trastuzumab, a potent antagonist of HER2, and using thiol chemistry to link the different Fabs together,...

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Detalles Bibliográficos
Autores principales: Scheer, Justin M., Sandoval, Wendy, Elliott, J. Michael, Shao, Lily, Luis, Elizabeth, Lewin-Koh, Sock-Cheng, Schaefer, Gabriele, Vandlen, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527469/
https://www.ncbi.nlm.nih.gov/pubmed/23284778
http://dx.doi.org/10.1371/journal.pone.0051817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527469/
https://www.ncbi.nlm.nih.gov/pubmed/23284778
http://dx.doi.org/10.1371/journal.pone.0051817

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