Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

BACKGROUND: Mesenchymal stem cells (MSCs) promote tumor growth by differentiating into carcinoma-associated fibroblasts (CAFs) and composing the tumor microenvironment. However, the mechanisms responsible for the transition of MSCs to CAFs are not well understood. Exosomes regulate cellular activiti...

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Detalles Bibliográficos
Autores principales: Gu, Jianmei, Qian, Hui, Shen, Li, Zhang, Xu, Zhu, Wei, Huang, Ling, Yan, Yongmin, Mao, Fei, Zhao, Chonghui, Shi, Yunyan, Xu, Wenrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527492/
https://www.ncbi.nlm.nih.gov/pubmed/23285052
http://dx.doi.org/10.1371/journal.pone.0052465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527492/
https://www.ncbi.nlm.nih.gov/pubmed/23285052
http://dx.doi.org/10.1371/journal.pone.0052465

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