ABT-737 Induces Bim Expression via JNK Signaling Pathway and Its Effect on the Radiation Sensitivity of HeLa Cells

ABT-737 is a BH3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic Bcl-2 family proteins including Bcl2, Bcl-xL and Bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-Bid, Bad, Bim). In this study, we demonstrate t...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Yang, Yue-Bo, Shen, Hui-Min, Gu, Jian, Li, Tian, Li, Xiao-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527555/
https://www.ncbi.nlm.nih.gov/pubmed/23285061
http://dx.doi.org/10.1371/journal.pone.0052483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527555/
https://www.ncbi.nlm.nih.gov/pubmed/23285061
http://dx.doi.org/10.1371/journal.pone.0052483

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