Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

BACKGROUND: Despite high cure rates for pediatric B-lineage acute lymphoblastic leukemia (B-ALL), short-term and long-term toxicities and chemoresistance are shortcomings of standard chemotherapy. Immunotherapy and chemoimmunotherapy based on monoclonal antibodies (mAbs) that target cell surface ant...

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Detalles Bibliográficos
Autores principales: Dave, Hema, Anver, Miriam R., Butcher, Donna O., Brown, Patrick, Khan, Javed, Wayne, Alan S., Baskar, Sivasubramanian, Rader, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527582/
https://www.ncbi.nlm.nih.gov/pubmed/23285131
http://dx.doi.org/10.1371/journal.pone.0052655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527582/
https://www.ncbi.nlm.nih.gov/pubmed/23285131
http://dx.doi.org/10.1371/journal.pone.0052655

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