Cargando…

Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms

Inactivation of the tumor suppressor gene p53 is commonly observed in human prostate cancer and is associated with therapeutic resistance. We have previously demonstrated that green tea polyphenols (GTP) induce apoptosis in prostate cancer cells irrespective of p53 status. However, the molecular mec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Karishma, Thakur, Vijay S., Bhaskaran, Natarajan, Nawab, Akbar, Babcook, Melissa A., Jackson, Mark W., Gupta, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527608/ https://www.ncbi.nlm.nih.gov/pubmed/23285096 http://dx.doi.org/10.1371/journal.pone.0052572

Ejemplares similares

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum
por: NAWAB, AKBAR, et al.
Publicado: (2012)

Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors.
por: McDonald, A. C., et al.
Publicado: (1998)

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
por: Sonnemann, J, et al.
Publicado: (2014)

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo
por: Kon, Ning, et al.
Publicado: (2019)

Green tea polyphenol sensing
por: TACHIBANA, Hirofumi
Publicado: (2011)

Resveratrol and Black Tea Polyphenol Combination Synergistically Suppress Mouse Skin Tumors Growth by Inhibition of Activated MAPKs and p53
por: George, Jasmine, et al.
Publicado: (2011)

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway
por: Maclaine, Nicola J., et al.
Publicado: (2009)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

Retraction: Resveratrol and Black Tea Polyphenol Combination Synergistically Suppress Mouse Skin Tumors Growth by Inhibition of Activated MAPKs and p53
Publicado: (2019)

RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53(abnormal) myeloma cells independently of the p53 pathway
por: Surget, Sylvanie, et al.
Publicado: (2014)

Immunomodulatory Effects of Green Tea Polyphenols †
por: Wang, Shuzhen, et al.
Publicado: (2021)

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs.
por: Malcomson, R. D., et al.
Publicado: (1995)

Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death
por: Okada, Hitoshi, et al.
Publicado: (2004)

Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
por: Hofstetter, G, et al.
Publicado: (2011)

Green Tea (Camellia sinensis) Extract Induces p53-Mediated Cytotoxicity and Inhibits Migration of Breast Cancer Cells
por: Santos, Ronimara A., et al.
Publicado: (2021)

p53 isoforms change p53 paradigm
por: Bourdon, JC
Publicado: (2014)

p53- and p73-independent activation of TIGAR expression in vivo
por: Lee, P, et al.
Publicado: (2015)

p21 can be a barrier to ferroptosis independent of p53
por: Venkatesh, Divya, et al.
Publicado: (2020)

p53 -Dependent and -Independent Nucleolar Stress Responses
por: Olausson, Karl Holmberg, et al.
Publicado: (2012)

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9
por: Tian, Xiaobing, et al.
Publicado: (2021)

p53 β-hydroxybutyrylation attenuates p53 activity
por: Liu, Kun, et al.
Publicado: (2019)

Understanding p53 functions through p53 antibodies
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

p53’s Extended Reach: The Mutant p53 Secretome
por: Pavlakis, Evangelos, et al.
Publicado: (2020)

Protective Mechanisms of Green Tea Polyphenols in Skin
por: OyetakinWhite, Patricia, et al.
Publicado: (2012)

Chronic Inflammatory Diseases and Green Tea Polyphenols
por: Oz, Helieh S.
Publicado: (2017)

D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
por: Aoubala, M, et al.
Publicado: (2010)

DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells
por: Cleaver, James E., et al.
Publicado: (2001)

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
por: Skwarska, Anna, et al.
Publicado: (2017)

Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms
por: Brown, Jeremy, et al.
Publicado: (2020)

The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity
por: Pant, Vinod, et al.
Publicado: (2013)

BTK modulates p73 activity to induce apoptosis independently of p53
por: Rada, Miran, et al.
Publicado: (2018)

Significance of p53 and ki-67 expression in prostate cancer
por: Verma, Renuka, et al.
Publicado: (2015)

OTUD5 Regulates p53 Stability by Deubiquitinating p53
por: Luo, Judong, et al.
Publicado: (2013)

The Δ133p53 Isoforms, Tuners of the p53 Pathway
por: Joruiz, Sebastien M., et al.
Publicado: (2020)

Corrigendum to ‘Understanding p53 functions through p53 antibodies’
por: Sabapathy, Kanaga, et al.
Publicado: (2019)

Structural insights into the transcription-independent apoptotic pathway of p53
por: Chi, Seung-Wook
Publicado: (2014)

Activation of Caspases in p53‐induced Transactivation‐independent Apoptosis
por: Gao, Chongfeng, et al.
Publicado: (1999)

APR-246 increases tumor antigenicity independent of p53
por: Michels, Judith, et al.
Publicado: (2023)

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity
por: Turrell, Frances K., et al.
Publicado: (2017)

Oncomir miR-125b Suppresses p14(ARF) to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer
por: Amir, Sumaira, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vusi95jfodcpsubk51n5ldgu70