The Binding Mode of Second-Generation Sulfonamide Inhibitors of MurD: Clues for Rational Design of Potent MurD Inhibitors

A series of optimized sulfonamide derivatives was recently reported as novel inhibitors of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). These are based on naphthalene-N-sulfonyl-D-glutamic acid and have the D-glutamic acid replaced with rigidified mimetics. Here we have defined the bind...

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Detalles Bibliográficos
Autores principales: Simčič, Mihael, Sosič, Izidor, Hodošček, Milan, Barreteau, Hélène, Blanot, Didier, Gobec, Stanislav, Grdadolnik, Simona Golič
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527612/
https://www.ncbi.nlm.nih.gov/pubmed/23285193
http://dx.doi.org/10.1371/journal.pone.0052817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527612/
https://www.ncbi.nlm.nih.gov/pubmed/23285193
http://dx.doi.org/10.1371/journal.pone.0052817

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