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Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany

In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak st...

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Autores principales: Merabishvili, Maia, De Vos, Daniel, Verbeken, Gilbert, Kropinski, Andrew M., Vandenheuvel, Dieter, Lavigne, Rob, Wattiau, Pierre, Mast, Jan, Ragimbeau, Catherine, Mossong, Joel, Scheres, Jacques, Chanishvili, Nina, Vaneechoutte, Mario, Pirnay, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528706/
https://www.ncbi.nlm.nih.gov/pubmed/23285164
http://dx.doi.org/10.1371/journal.pone.0052709
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author Merabishvili, Maia
De Vos, Daniel
Verbeken, Gilbert
Kropinski, Andrew M.
Vandenheuvel, Dieter
Lavigne, Rob
Wattiau, Pierre
Mast, Jan
Ragimbeau, Catherine
Mossong, Joel
Scheres, Jacques
Chanishvili, Nina
Vaneechoutte, Mario
Pirnay, Jean-Paul
author_facet Merabishvili, Maia
De Vos, Daniel
Verbeken, Gilbert
Kropinski, Andrew M.
Vandenheuvel, Dieter
Lavigne, Rob
Wattiau, Pierre
Mast, Jan
Ragimbeau, Catherine
Mossong, Joel
Scheres, Jacques
Chanishvili, Nina
Vaneechoutte, Mario
Pirnay, Jean-Paul
author_sort Merabishvili, Maia
collection PubMed
description In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections.
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spelling pubmed-35287062013-01-02 Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany Merabishvili, Maia De Vos, Daniel Verbeken, Gilbert Kropinski, Andrew M. Vandenheuvel, Dieter Lavigne, Rob Wattiau, Pierre Mast, Jan Ragimbeau, Catherine Mossong, Joel Scheres, Jacques Chanishvili, Nina Vaneechoutte, Mario Pirnay, Jean-Paul PLoS One Research Article In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections. Public Library of Science 2012-12-21 /pmc/articles/PMC3528706/ /pubmed/23285164 http://dx.doi.org/10.1371/journal.pone.0052709 Text en © 2012 Merabishvili et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Merabishvili, Maia
De Vos, Daniel
Verbeken, Gilbert
Kropinski, Andrew M.
Vandenheuvel, Dieter
Lavigne, Rob
Wattiau, Pierre
Mast, Jan
Ragimbeau, Catherine
Mossong, Joel
Scheres, Jacques
Chanishvili, Nina
Vaneechoutte, Mario
Pirnay, Jean-Paul
Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title_full Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title_fullStr Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title_full_unstemmed Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title_short Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
title_sort selection and characterization of a candidate therapeutic bacteriophage that lyses the escherichia coli o104:h4 strain from the 2011 outbreak in germany
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528706/
https://www.ncbi.nlm.nih.gov/pubmed/23285164
http://dx.doi.org/10.1371/journal.pone.0052709
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