NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the function of these professional phagocytes in an autocrine manner. Expression of a DsRed2 fluorescent reporter...

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Detalles Bibliográficos
Autores principales: Muxel, Sandra Marcia, Pires-Lapa, Marco Antonio, Monteiro, Alex Willian Arantes, Cecon, Erika, Tamura, Eduardo Koji, Floeter-Winter, Lucile Maria, Markus, Regina P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528721/
https://www.ncbi.nlm.nih.gov/pubmed/23284853
http://dx.doi.org/10.1371/journal.pone.0052010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528721/
https://www.ncbi.nlm.nih.gov/pubmed/23284853
http://dx.doi.org/10.1371/journal.pone.0052010

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