Alterations in Glutathione Levels and Apoptotic Regulators Are Associated with Acquisition of Arsenic Trioxide Resistance in Multiple Myeloma

Arsenic trioxide (ATO) has been tested in relapsed/refractory multiple myeloma with limited success. In order to better understand drug mechanism and resistance pathways in myeloma we generated an ATO-resistant cell line, 8226/S-ATOR05, with an IC50 that is 2–3-fold higher than control cell lines an...

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Detalles Bibliográficos
Autores principales: Matulis, Shannon M., Morales, Alejo A., Yehiayan, Lucy, Lee, Kelvin P., Cai, Yong, Boise, Lawrence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528737/
https://www.ncbi.nlm.nih.gov/pubmed/23285138
http://dx.doi.org/10.1371/journal.pone.0052662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528737/
https://www.ncbi.nlm.nih.gov/pubmed/23285138
http://dx.doi.org/10.1371/journal.pone.0052662

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