Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220(+) Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice

Lupus is a chronic inflammatory autoimmune disease influenced by multiple genetic loci including Fas Ligand (FasL) and P2X7 receptor (P2X7R). The Fas/Fas Ligand apoptotic pathway is critical for immune homeostasis and peripheral tolerance. Normal effector T lymphocytes up-regulate the transmembrane...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Gall, Sylvain M., Legrand, Julie, Benbijja, Mohcine, Safya, Hanaa, Benihoud, Karim, Kanellopoulos, Jean M., Bobé, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528777/
https://www.ncbi.nlm.nih.gov/pubmed/23284917
http://dx.doi.org/10.1371/journal.pone.0052161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528777/
https://www.ncbi.nlm.nih.gov/pubmed/23284917
http://dx.doi.org/10.1371/journal.pone.0052161

Ejemplares similares