Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)

The Topoisomerase II (topo II) DNA incision and ligation cycle can be poisoned (e.g following treatment with cancer chemotherapeutics) to generate cytotoxic DNA double strand breaks (DSBs) with topo II covalently conjugated to DNA. Tyrosyl-DNA phosphodiesterase 2 (Tdp2) protects genomic integrity by...

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Detalles Bibliográficos
Autores principales: Schellenberg, Matthew J., Appel, C. Denise, Adhikari, Sanjay, Robertson, Patrick D., Ramsden, Dale A., Williams, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529160/
https://www.ncbi.nlm.nih.gov/pubmed/23104055
http://dx.doi.org/10.1038/nsmb.2418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529160/
https://www.ncbi.nlm.nih.gov/pubmed/23104055
http://dx.doi.org/10.1038/nsmb.2418

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