Novel Computational Methodologies for Structural Modeling of Spacious Ligand Binding Sites of G-Protein-Coupled Receptors: Development and Application to Human Leukotriene B4 Receptor

This paper describes a novel method to predict the activated structures of G-protein-coupled receptors (GPCRs) with high accuracy, while aiming for the use of the predicted 3D structures in in silico virtual screening in the future. We propose a new method for modeling GPCR thermal fluctuations, whe...

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Detalles Bibliográficos
Autores principales: Ishino, Yoko, Harada, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529862/
https://www.ncbi.nlm.nih.gov/pubmed/23304088
http://dx.doi.org/10.1100/2012/691579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529862/
https://www.ncbi.nlm.nih.gov/pubmed/23304088
http://dx.doi.org/10.1100/2012/691579

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