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The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

The Keap1–Nrf2 [Kelch-like ECH-associated protein 1–nuclear factor (erythroid-derived 2)-like 2] pathway plays a central role in the protection of cells against oxidative and xenobiotic stresses. Nrf2 is a potent transcription activator that recognizes a unique DNA sequence known as the antioxidant...

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Detalles Bibliográficos
Autores principales: Mitsuishi, Yoichiro, Motohashi, Hozumi, Yamamoto, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530133/
https://www.ncbi.nlm.nih.gov/pubmed/23272301
http://dx.doi.org/10.3389/fonc.2012.00200