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HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
Human CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs) control effector T cells and play a central role in peripheral tolerance and immune homeostasis. Heat shock protein 70 (HSP70) is a major immunomodulatory molecule, but its effect on the functions of Tregs is not well understood. To investigate...
Autores principales: | Wachstein, Julian, Tischer, Sabine, Figueiredo, Constanca, Limbourg, Anne, Falk, Christine, Immenschuh, Stephan, Blasczyk, Rainer, Eiz-Vesper, Britta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530531/ https://www.ncbi.nlm.nih.gov/pubmed/23300563 http://dx.doi.org/10.1371/journal.pone.0051747 |
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