Effective Inhibition of Human Immunodeficiency Virus 1 Replication by Engineered RNase P Ribozyme

Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...

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Detalles Bibliográficos
Autores principales: Zeng, Wenbo, Chen, Yuan-Chuan, Bai, Yong, Trang, Phong, Vu, Gia-Phong, Lu, Sangwei, Wu, Jianguo, Liu, Fenyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530568/
https://www.ncbi.nlm.nih.gov/pubmed/23300569
http://dx.doi.org/10.1371/journal.pone.0051855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530568/
https://www.ncbi.nlm.nih.gov/pubmed/23300569
http://dx.doi.org/10.1371/journal.pone.0051855

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