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Effective Inhibition of Human Immunodeficiency Virus 1 Replication by Engineered RNase P Ribozyme
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530568/ https://www.ncbi.nlm.nih.gov/pubmed/23300569 http://dx.doi.org/10.1371/journal.pone.0051855 |