PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model

PG545 is a clinically relevant heparan sulfate (HS) mimetic which, in addition to possessing anti-angiogenic properties, also acts as a heparanase inhibitor which may differentiate its mechanism(s) of action from approved angiogenesis inhibitors. The degradation of HS by heparanase has been strongly...

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Detalles Bibliográficos
Autores principales: Hammond, Edward, Brandt, Ralf, Dredge, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530599/
https://www.ncbi.nlm.nih.gov/pubmed/23300607
http://dx.doi.org/10.1371/journal.pone.0052175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530599/
https://www.ncbi.nlm.nih.gov/pubmed/23300607
http://dx.doi.org/10.1371/journal.pone.0052175

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