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Molecular modeling, docking and ADMET studies towards development of novel Disopyramide analogs for potential inhibition of human voltage gated sodium channel proteins
The sodium “channelopathies” are the first among the ion channel diseases identified and have attracted widespread clinical and scientific interests. Human voltage gated sodium channels are sites of action of several antiarrhythmic drugs, local anesthetics and related antiepileptic drugs. The presen...
Autores principales: | Meraj, Khunza, Mahto, Manoj Kumar, Christina, N Blessy, Desai, Nidhi, Shahbazi, Sajad, Bhaskar, Matcha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530882/ https://www.ncbi.nlm.nih.gov/pubmed/23275710 http://dx.doi.org/10.6026/97320630081139 |
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