The anti-viral factor APOBEC3G enhances natural killer cell recognition of HIV-infected primary T cells

APOBEC3G (A3G) is an intrinsic antiviral factor that inhibits HIV replication by deaminating cytidine residues to uridine. This causes G-to-A hypermutation in the opposite strand and results in viral inactivation. HIV counteracts A3G through the activity of viral infectivity factor (Vif), which prom...

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Detalles Bibliográficos
Autores principales: Norman, Jason M., Mashiba, Michael, McNamara, Lucy A, Onafuwa-Nuga, Adewunmi, Chiari-Fort, Estelle, Shen, Wenwen, Collins, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530928/
https://www.ncbi.nlm.nih.gov/pubmed/21874023
http://dx.doi.org/10.1038/ni.2087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530928/
https://www.ncbi.nlm.nih.gov/pubmed/21874023
http://dx.doi.org/10.1038/ni.2087

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