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Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[(11) C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([(11) C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
BACKGROUND: Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeutic potential. Positron emission tomography (PET) imaging probes for GlyT1 are,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531252/ https://www.ncbi.nlm.nih.gov/pubmed/22776065 http://dx.doi.org/10.1186/2191-219X-2-37 |