Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[(11) C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([(11) C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

BACKGROUND: Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeutic potential. Positron emission tomography (PET) imaging probes for GlyT1 are,...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuchigami, Takeshi, Takano, Akihiro, Gulyás, Balázs, Jia, Zhisheng, Finnema, Sjoerd J, Andersson, Jan D, Nakao, Ryuji, Magata, Yasuhiro, Haratake, Mamoru, Nakayama, Morio, Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531252/
https://www.ncbi.nlm.nih.gov/pubmed/22776065
http://dx.doi.org/10.1186/2191-219X-2-37

Ejemplares similares

Ejemplares similares