Cargando…

Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin Receptor

The hormone thyrotropin (TSH) and its receptor (TSHR) are crucial for the growth and function of the thyroid gland. The TSHR is evolutionary linked with the receptors of follitropin (FSHR) and lutropin/choriogonadotropin (LHR) and their sequences and structures are similar. The extracellular region...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krause, Gerd, Kreuchwig, Annika, Kleinau, Gunnar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531376/ https://www.ncbi.nlm.nih.gov/pubmed/23300822 http://dx.doi.org/10.1371/journal.pone.0052920

Ejemplares similares

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work
por: Kleinau, Gunnar, et al.
Publicado: (2017)

GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
por: Worth, Catherine L, et al.
Publicado: (2011)

Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor’s Extracellular Hinge Region
por: Grzesik, Paul, et al.
Publicado: (2015)

Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor
por: Kleinau, Gunnar, et al.
Publicado: (2010)

GPCR-SSFE 2.0—a fragment-based molecular modeling web tool for Class A G-protein coupled receptors
por: Worth, Catherine L., et al.
Publicado: (2017)

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists
por: Hoyer, Inna, et al.
Publicado: (2013)

Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation
por: Biebermann, Heike, et al.
Publicado: (2011)

Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells
por: Boutin, Alisa, et al.
Publicado: (2016)

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling
por: Lazzaretti, Clara, et al.
Publicado: (2020)

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models
por: Worth, Catherine L., et al.
Publicado: (2009)

Molecular basis for the activation of thyrotropin-releasing hormone receptor
por: Ji, Su-Yu, et al.
Publicado: (2022)

Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor
por: Chantreau, Vanessa, et al.
Publicado: (2015)

GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin β Gene
por: Ohba, Kenji, et al.
Publicado: (2011)

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor
por: Thirunarayanan, Nanthakumar, et al.
Publicado: (2012)

Desensitization, Trafficking, and Resensitization of the Pituitary Thyrotropin-Releasing Hormone Receptor
por: Hinkle, Patricia M., et al.
Publicado: (2012)

Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production
por: Ke, Sujie, et al.
Publicado: (2021)

Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue
por: Yang, Fan, et al.
Publicado: (2022)

SUN-465 Thyrotropin-Releasing Hormone-Degrading Ectoenzyme Controls Thyrotropin Secretion and Body Weight in Male Rodents
por: Charli, Jean-Louis, et al.
Publicado: (2019)

The Antagonist pGlu-βGlu-Pro-NH(2) Binds to an Allosteric Site of the Thyrotropin-Releasing Hormone Receptor
por: De La Cruz, Daniel L., et al.
Publicado: (2021)

Investigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas
por: Chin, Sang Ouk, et al.
Publicado: (2013)

Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens
por: Li, Xiaoxiao, et al.
Publicado: (2019)

Factors modulating the secretion of thyrotropin and other hormones of the thyroid axis.
por: Hedge, G A, et al.
Publicado: (1981)

Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
por: Rijks, Jesse, et al.
Publicado: (2016)

The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?
por: Charli, Jean-Louis, et al.
Publicado: (2020)

Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
por: Rodríguez-Rodríguez, Adair, et al.
Publicado: (2019)

Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei
por: Sánchez-Jaramillo, Edith, et al.
Publicado: (2022)

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83
por: Müller, Anne, et al.
Publicado: (2016)

Thyrotropin Binding Inhibiting Antibody (TBIAb) in Graves’ Disease
por: Cho, Won Yong, et al.
Publicado: (1988)

Monoclonal Antibodies to the Thyrotropin Receptor
por: Ando, Takao, et al.
Publicado: (2005)

Thyrotropin Receptor Blocking Antibodies
por: Diana, Tanja, et al.
Publicado: (2018)

Author Correction: Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue
por: Yang, Fan, et al.
Publicado: (2022)

Intrauterine Zn Deficiency Favors Thyrotropin-Releasing Hormone-Increasing Effects on Thyrotropin Serum Levels and Induces Subclinical Hypothyroidism in Weaned Rats
por: Alcántara-Alonso, Viridiana, et al.
Publicado: (2017)

The Role of Thyrotropin-Releasing Hormone Stimulation Test in Management of Hyperthyrotropinemia in Infants
por: Altıncık, Ayça, et al.
Publicado: (2015)

The Effect of Thyrotropin-Releasing Hormone and Antithyroid Drugs on Fetal Thyroid Function
por: Vrachnis, Nikolaos, et al.
Publicado: (2021)

An Aggressive Plurihormonal Pituitary Adenoma With Thyrotropin, Growth Hormone, and Prolactin Excess
por: Goh, QingCi, et al.
Publicado: (2023)

Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling
por: Wichard, Jörg D., et al.
Publicado: (2011)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective
por: Heyder, Nicolas, et al.
Publicado: (2019)

Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution
por: Maugars, Gersende, et al.
Publicado: (2014)

Thyrotropin receptor antibodies and Graves’ orbitopathy
por: Diana, T., et al.
Publicado: (2020)

The Intracellular Localization of Hormonal Activity in Transplantable Thyrotropin-Secreting Pituitary Tumors in Mice
por: Kamat, Virendra B., et al.
Publicado: (1960)

Cannot write session to /tmp/vufind_sessions/sess_0utj8d8fociju4ld0a0jcpqjso