A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy. Several classes of small-molecules that activate the p53 pathway have been discovered us...

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Detalles Bibliográficos
Autores principales: Dai, Fujun, Chen, Yihua, Song, Yajuan, Huang, Li, Zhai, Dong, Dong, Yanmin, Lai, Li, Zhang, Tao, Li, Dali, Pang, Xiufeng, Liu, Mingyao, Yi, Zhengfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531399/
https://www.ncbi.nlm.nih.gov/pubmed/23300602
http://dx.doi.org/10.1371/journal.pone.0052162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531399/
https://www.ncbi.nlm.nih.gov/pubmed/23300602
http://dx.doi.org/10.1371/journal.pone.0052162

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