Uncoupling Proteostasis and Development in Vitro with a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

Loss-of-function mutations in EIF2AK3, encoding the pancreatic endoplasmic reticulum (ER) kinase, PERK, are associated with dysfunction of the endocrine pancreas and diabetes. However, to date it has not been possible to uncouple the long term developmental effects of PERK deficiency from sensitizat...

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Detalles Bibliográficos
Autores principales: Harding, Heather P., Zyryanova, Alisa F., Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531748/
https://www.ncbi.nlm.nih.gov/pubmed/23148209
http://dx.doi.org/10.1074/jbc.M112.428987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531748/
https://www.ncbi.nlm.nih.gov/pubmed/23148209
http://dx.doi.org/10.1074/jbc.M112.428987

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