Somatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells

Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variations (CNVs)(1-4). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 indi...

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Detalles Bibliográficos
Autores principales: Abyzov, Alexej, Mariani, Jessica, Palejev, Dean, Zhang, Ying, Haney, Michael Seamus, Tomasini, Livia, Ferrandino, Anthony, Belmaker, Lior A. Rosenberg, Szekely, Anna, Wilson, Michael, Kocabas, Arif, Calixto, Nathaniel E., Grigorenko, Elena L., Huttner, Anita, Chawarska, Katarzyna, Weissman, Sherman, Urban, Alexander Eckehart, Gerstein, Mark, Vaccarino, Flora M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532053/
https://www.ncbi.nlm.nih.gov/pubmed/23160490
http://dx.doi.org/10.1038/nature11629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532053/
https://www.ncbi.nlm.nih.gov/pubmed/23160490
http://dx.doi.org/10.1038/nature11629

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