The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia (S1P(1)) and Hypertension (S1P(3)) in Rat

Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P(X) receptor agonist) produces modest hypertension in patients (2–3 mmHg in 1-yr trial) as well as acute bradycardia independent of changes in bl...

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Detalles Bibliográficos
Autores principales: Fryer, Ryan M., Muthukumarana, Akalushi, Harrison, Paul C., Nodop Mazurek, Suzanne, Chen, Rong Rhonda, Harrington, Kyle E., Dinallo, Roger M., Horan, Joshua C., Patnaude, Lori, Modis, Louise K., Reinhart, Glenn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532212/
https://www.ncbi.nlm.nih.gov/pubmed/23285242
http://dx.doi.org/10.1371/journal.pone.0052985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532212/
https://www.ncbi.nlm.nih.gov/pubmed/23285242
http://dx.doi.org/10.1371/journal.pone.0052985

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