Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1

BACKGROUND: STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) (702)IKTE(705) is localized in the C-terminal region of STAT1, where Lys703 is a target for PIAS-induced SUMO modification. Several studies indicate that sumo...

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Detalles Bibliográficos
Autores principales: Grönholm, Juha, Vanhatupa, Sari, Ungureanu, Daniela, Väliaho, Jouni, Laitinen, Tuomo, Valjakka, Jarkko, Silvennoinen, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532225/
https://www.ncbi.nlm.nih.gov/pubmed/23043228
http://dx.doi.org/10.1186/1471-2091-13-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532225/
https://www.ncbi.nlm.nih.gov/pubmed/23043228
http://dx.doi.org/10.1186/1471-2091-13-20

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