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Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1

BACKGROUND: STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) (702)IKTE(705) is localized in the C-terminal region of STAT1, where Lys703 is a target for PIAS-induced SUMO modification. Several studies indicate that sumo...

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Detalles Bibliográficos
Autores principales:	Grönholm, Juha, Vanhatupa, Sari, Ungureanu, Daniela, Väliaho, Jouni, Laitinen, Tuomo, Valjakka, Jarkko, Silvennoinen, Olli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532225/ https://www.ncbi.nlm.nih.gov/pubmed/23043228 http://dx.doi.org/10.1186/1471-2091-13-20

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