Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3

SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Tao, Xu, Chao, Liu, Yanli, Fan, Kai, Li, Zhihong, Sun, Xing, Ouyang, Hui, Zhang, Xuecheng, Zhang, Jiahai, Li, Yanjun, MacKenzie, Farrell, Min, Jinrong, Tu, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532415/
https://www.ncbi.nlm.nih.gov/pubmed/23285239
http://dx.doi.org/10.1371/journal.pone.0052977
_version_ 1782254308313530368
author Wang, Tao
Xu, Chao
Liu, Yanli
Fan, Kai
Li, Zhihong
Sun, Xing
Ouyang, Hui
Zhang, Xuecheng
Zhang, Jiahai
Li, Yanjun
MacKenzie, Farrell
Min, Jinrong
Tu, Xiaoming
author_facet Wang, Tao
Xu, Chao
Liu, Yanli
Fan, Kai
Li, Zhihong
Sun, Xing
Ouyang, Hui
Zhang, Xuecheng
Zhang, Jiahai
Li, Yanjun
MacKenzie, Farrell
Min, Jinrong
Tu, Xiaoming
author_sort Wang, Tao
collection PubMed
description SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of the chromodomain of human SUV39H1 was determined by X-ray crystallography. The SUV39H1 chromodomain displays a generally conserved structure fold compared with other solved chromodomains. However, different from other chromodomains, the SUV39H1 chromodomain possesses a much longer helix at its C-terminus. Furthermore, the SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically.
format Online
Article
Text
id pubmed-3532415
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35324152013-01-02 Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3 Wang, Tao Xu, Chao Liu, Yanli Fan, Kai Li, Zhihong Sun, Xing Ouyang, Hui Zhang, Xuecheng Zhang, Jiahai Li, Yanjun MacKenzie, Farrell Min, Jinrong Tu, Xiaoming PLoS One Research Article SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of the chromodomain of human SUV39H1 was determined by X-ray crystallography. The SUV39H1 chromodomain displays a generally conserved structure fold compared with other solved chromodomains. However, different from other chromodomains, the SUV39H1 chromodomain possesses a much longer helix at its C-terminus. Furthermore, the SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically. Public Library of Science 2012-12-28 /pmc/articles/PMC3532415/ /pubmed/23285239 http://dx.doi.org/10.1371/journal.pone.0052977 Text en © 2012 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Tao
Xu, Chao
Liu, Yanli
Fan, Kai
Li, Zhihong
Sun, Xing
Ouyang, Hui
Zhang, Xuecheng
Zhang, Jiahai
Li, Yanjun
MacKenzie, Farrell
Min, Jinrong
Tu, Xiaoming
Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title_full Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title_fullStr Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title_full_unstemmed Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title_short Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
title_sort crystal structure of the human suv39h1 chromodomain and its recognition of histone h3k9me2/3
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532415/
https://www.ncbi.nlm.nih.gov/pubmed/23285239
http://dx.doi.org/10.1371/journal.pone.0052977
work_keys_str_mv AT wangtao crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT xuchao crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT liuyanli crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT fankai crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT lizhihong crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT sunxing crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT ouyanghui crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT zhangxuecheng crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT zhangjiahai crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT liyanjun crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT mackenziefarrell crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT minjinrong crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23
AT tuxiaoming crystalstructureofthehumansuv39h1chromodomainanditsrecognitionofhistoneh3k9me23

Ejemplares similares