Cargando…

Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data

Drug-induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug effect can occur in various tissues and is suspected to impact cellular viability. Therefore, it is important to test chemical compounds for t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muehlbacher, Markus, Tripal, Philipp, Roas, Florian, Kornhuber, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533795/ https://www.ncbi.nlm.nih.gov/pubmed/22945602 http://dx.doi.org/10.1002/cmdc.201200306

Ejemplares similares

Predicting the mechanism of phospholipidosis
por: Lowe, Robert, et al.
Publicado: (2012)

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase
por: Kornhuber, Johannes, et al.
Publicado: (2011)

Renal phospholipidosis possibly induced by ranolazine
por: Scheurle, Christoph, et al.
Publicado: (2014)

Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs
por: Öhlinger, Kristin, et al.
Publicado: (2020)

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
por: Tummino, Tia A., et al.
Publicado: (2021)

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2021)

Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis
por: Lee, Ji-Young, et al.
Publicado: (2020)

Zebra Body Formation Due to Drug-Induced Phospholipidosis Observed on Electron Micrographs
por: Kawahara, Hiroshi, et al.
Publicado: (2021)

Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues
por: Rotimi, Solomon O, et al.
Publicado: (2015)

Predicting Phospholipidosis Using Machine Learning
por: Lowe, Robert, et al.
Publicado: (2010)

Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.
por: Antonini, J M, et al.
Publicado: (1994)

Increased Density of the Liver and Amiodarone-Associated Phospholipidosis
por: Kojima, Sunao, et al.
Publicado: (2009)

Curvilinear bodies in hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease
por: Costa, Rui M., et al.
Publicado: (2013)

Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits
por: Yamagiwa, Yoshinori, et al.
Publicado: (2016)

Case report of progressive renal dysfunction as a consequence of amiodarone-induced phospholipidosis
por: Duineveld, Mirjam D, et al.
Publicado: (2023)

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis
por: Pradip, Arvind, et al.
Publicado: (2016)

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2
por: Tummino, Tia A., et al.
Publicado: (2021)

Qualitative prediction of blood–brain barrier permeability on a large and refined dataset
por: Muehlbacher, Markus, et al.
Publicado: (2011)

Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific
por: Diesendorf, Viktoria, et al.
Publicado: (2023)

Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis
por: Patel, Aateka, et al.
Publicado: (2019)

Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report
por: Wu, Song-Zhao, et al.
Publicado: (2019)

Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
por: Yang, Yang, et al.
Publicado: (2016)

Attenuation of amiodarone induced lung fibrosis and phospholipidosis in hamsters, by treatment with the platelet activating factor receptor antagonist, WEB 2086
por: Giri, S. N., et al.
Publicado: (1993)

Identification of Immunopotentiating Lactic Acid Bacteria that Induce Antibody Production by in vitro Stimulated Human Peripheral Blood Mononuclear Cells
por: YAMASHITA, Makiko, et al.
Publicado: (2012)

Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs
por: Cimic, Adela, et al.
Publicado: (2013)

Post-transplant de-novo renal phospholipidosis in a kidney transplant recipient: Fabry disease or something else?
por: Naseer, Muhammad Saad, et al.
Publicado: (2020)

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants
por: Rhein, Cosima, et al.
Publicado: (2012)

Identification of Novel Genes Selectively Expressed in the Follicle-Associated Epithelium from the Meta-Analysis of Transcriptomics Data from Multiple Mouse Cell and Tissue Populations
por: Kobayashi, Atsushi, et al.
Publicado: (2012)

Hydroxychloroquine: Acute kidney injury, prolonged QTC interval and renal phospholipidosis following off-label use: case report
Publicado: (2021)

Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N‐Functionalized Tertiary Sulfonimidamides
por: Izzo, Flavia, et al.
Publicado: (2018)

Comparison of the Accuracy and Mechanism of Data Mining Identification of the Intestinal Microbiota with 7 Restriction Enzymes
por: KOBAYASHI, Toshio, et al.
Publicado: (2013)

Oxygen Reduction and Evolution on Ni‐modified Co(3)O(4)(1 1 1) Cathodes for Zn–Air Batteries: A Combined Surface Science and Electrochemical Model Study
por: Buchner, Florian, et al.
Publicado: (2020)

Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo
por: Bande, Omprakash, et al.
Publicado: (2015)

Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates
por: Sirvent, Juan Alberto, et al.
Publicado: (2017)

Identification of a Novel Parallel β‐Strand Conformation within Molecular Monolayer of Amyloid Peptide
por: Liu, Lei, et al.
Publicado: (2016)

Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro
por: Abeln, Markus, et al.
Publicado: (2017)

Synthesis of Highly Functionalizable Symmetrically and Unsymmetrically Substituted Triarylboranes from Bench‐Stable Boron Precursors
por: Ferger, Matthias, et al.
Publicado: (2021)

Synthesis and in Vitro Evaluation of Novel 5‐Nitroindole Derivatives as c‐Myc G‐Quadruplex Binders with Anticancer Activity
por: Nimbarte, Vijaykumar D., et al.
Publicado: (2021)

Tiling Assembly: a new tool for reference annotation-independent transcript assembly and novel gene identification by RNA-sequencing
por: Watanabe, Kenneth A., et al.
Publicado: (2015)

Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database
por: Southan, Christopher, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_i2uudarc8li9s74ul45tf57d8j