Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal α-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition

Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent prote...

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Detalles Bibliográficos
Autores principales: Morgan, Rhodri M. L., Hernández-Ramírez, Laura C., Trivellin, Giampaolo, Zhou, Lihong, Roe, S. Mark, Korbonits, Márta, Prodromou, Chrisostomos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534021/
https://www.ncbi.nlm.nih.gov/pubmed/23300914
http://dx.doi.org/10.1371/journal.pone.0053339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534021/
https://www.ncbi.nlm.nih.gov/pubmed/23300914
http://dx.doi.org/10.1371/journal.pone.0053339

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